- In a high profile product placement deal, General Motors donated two GMC Yukon XL Denalis to the Los Angeles and Las Vegas police departments. The same model vehicles were modified and used on the show as the "Mobile Analysis Unit", or MAU, in the same episode directed by Tarantino, the season five finale "Grave Danger". The vehicles were given a six inch height difference from stock models, allowing the trunk lid to be used by the characters as a rain shield, and the rear bay and third-row area as a mobile lab, complete with notebook computers, equipment drawers and storage. (Direct from Wikipedia)
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- In later seasons, the spider behind Grissom's desk only has 7 legs.
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- The season 8 episode, 'Lying Down With Dogs' was recently nominated for a Genesis award which are given to members of the media who bring attention to animal rights. CSI was nominated in the Dramatic Series category and they took home the award, "For shedding light on the brutality of dog fighting with a plot that reveals a victim's sadistic life as a dog fighter may have led to her vengeful murder." Read the full article here.
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- When CSI first aired, it was on Friday nights after The Fugitive but because of the success it got moved to Thursday nights where it was up against other popular TV shows.
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- The choice to place this series in Las Vegas was not random. Among US crime labs, Las Vegas is the second most active, surpassed only by the FBI lab at Quantico, Virginia.
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- Holly Gribbs was supposed to be a regular on the series, but her character was not liked by many of the test audiences. So, Holly did not survive the shooting and the character of Sara Sidle was created.
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- The actual Las Vegas Police Department's crime scene division is called the "Crime Scene Unit (CSU)" not "Crime Scene Investigation (CSI)" as is done from this point on through the series.
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